Orally, betony is used for diarrhea, stress and tension, headache, epilepsy, facial pain, as an expectorant for cough, bronchitis, asthma, as an antiflatulent, and as a sedative. It has also been employed to treat heartburn, gout, nervousness, bladder and kidney stones (nephrolithiasis), and for bladder inflammation.

In combination with other herbs, betony is used to treat neuralgia and anxiety.

As an aromatic, it has also astringent and alterative action, and combined with other remedies is used as a tonic in dyspepsia and as an alterative in rheumatism, scrofula, and impurities of the blood.